6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells
نویسندگان
چکیده
منابع مشابه
Mitochondrial DNA, mitochondrial dysfunction, and cardiac manifestations.
Mitochondria, are the powerhouses of cells, have their own DNA (mtDNA), regulate the transport of metabolites and ions, and impact cell physiology, survival, and death. Mitochondrial dysfunction, including impaired oxidative phosphorylation, preferentially affects heart function due to an imbalance of energy supply and demand. Recently, mitochondrial mutations and associated mitochondrial dysfu...
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Background: Increased mitochondrial DNA copy number (mtDNAcn) is a biological response to mtDNA damage and dysfunction predictive of lung cancer risk. Polycyclic aromatic hydrocarbons (PAHs) are established lung carcinogens and may cause mitochondrial toxicity. Whether PAH exposure and PAHrelated nuclear DNA (nDNA) genotoxic effects are linked with increased mtDNAcn has never been evaluated. Me...
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In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting mitochondrial respiratory complex I. This initiated the long-standing hypothesis that mitochondrial dysfunction may play a key role in the pathogenesis of Parkinson's disease (PD). This hypothesis evolved, with accumulating evidence pointing to complex I dysfunction, which could be caused by environmental or genet...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2011
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2011.10.040